PE/Cyanine7 anti-human CD38 Antibody

Pricing & Availability
Clone
HIT2 (See other available formats)
Regulatory Status
RUO
Workshop
III 155
Other Names
T10, ADP-ribosyl cyclase
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HIT2_PECy7_021009.jpg
Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
  • HIT2_PECy7_021009.jpg
    Human peripheral blood lymphocytes stained with HIT2 PE/Cyanine7
Compare all formats See PE/Cyanine7 spectral data
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303515 25 tests 143 CHF
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303516 100 tests 292 CHF
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Description

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee, Horse, Cow
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections6 and spatial biology (IBEX)10,11.

Additional Product Notes

BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.

Application References

(PubMed link indicates BioLegend citation)
  1. Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dieu M. 1998. J. Exp. Med. 188:373.
  3. Esser M, et al. 2001. J. Virol. 75:6173.
  4. Jeannin P, et al. 1999. J. Immunol. 162:2044.
  5. Kapsogeorgou EK, et al. 2001. J. Immunol. 166:3107.
  6. van der Voort R, et al. 1997. J. Exp. Med. 185:2121. (IHC)
  7. Bende RJ, et al. 2003. Am. J. Pathol. 162:105.
  8. Lehner M, et al. 2008. J. Leukoc. Biol. 83:883. PubMed
  9. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  10. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  11. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Hofmann M, et al. 2012. Leukemia. 26:1288. PubMed
  2. Weinberg A, et al. 2015. PLoS One. 10:122431. PubMed
  3. Boisson B, et al. 2015. J Exp Med. 212:939. PubMed
  4. Inui M, et al. 2015. Int Immunol. 27: 345 - 355. PubMed
  5. Lorkova L, et al. 2015. PLoS One. 10: 0135314. PubMed
  6. Ishizaka A, et al. 2016. J Virol. 90: 5665 - 5676. PubMed
  7. Hoffmann M, et al. 2016. PLoS Pathog. 12: 1005661. PubMed
  8. Nagafuchi Y, et al. 2016. Sci Rep. 6:29338. PubMed
  9. S Tzeng 2016. J Vis Exp. 118:e54582. PubMed
  10. Tsuchida Y, et al. 2017. PLoS One. 10.1371/journal.pone.0169646. PubMed
  11. , et al. 2020. Haematologica. 105:2795. PubMed
  12. Trivedi S, et al. 2020. Elife. 9:00. PubMed
  13. Riether C, et al. 2021. Cell Reports. 34(4):108663. PubMed
  14. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  15. Audigé A, et al. 2017. BMC Immunology. 10.1186/s12865-017-0209-9. PubMed
  16. Shoda H, et al. 2017. Arthritis Research & Therapy . 10.1186/s13075-017-1308-y. PubMed
  17. Setliff I, et al. 2018. Cell Host Microbe. 23:845. PubMed
  18. Dutta AK, et al. 2019. Leukemia. 33:457. PubMed
  19. Neu KE, et al. 2019. J Clin Invest. 129:93. PubMed
  20. Fu J et al. 2019. Cell stem cell. 24(2):227-239 . PubMed
  21. Shan L, et al. 2017. Immunity. 47:766. PubMed
  22. Salazar-Camarena DC, et al. 2020. Sci Rep. 10:6236. PubMed
  23. Singh A, et al. 2020. Cell Rep. 32:108153. PubMed
  24. Katsuyama E, et al. 2020. Cell Reports. 30(1):112-123.e4.. PubMed
  25. Chaimowitz N, et al. 2011. J Immunol. 187:5114. PubMed
RRID
AB_1279235 (BioLegend Cat. No. 303515)
AB_2072782 (BioLegend Cat. No. 303516)

Antigen Details

Structure
ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD
Distribution

T cells, B cells, NK, myeloid, plasma, and dendritic cells

Function
Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation
Ligand/Receptor
CD31, hyaluronic acid
Cell Type
B cells, Dendritic cells, NK cells, Plasma cells, T cells
Biology Area
Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Ferrero E, et al. 1999. J. Leukoc. Biol. 65:151.
2. Lund F, et al. 1995. Immunol. Today 16:469.

Gene ID
952 View all products for this Gene ID
UniProt
View information about CD38 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 12.17.2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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