APC anti-human CD151 (PETA-3) Antibody

Pricing & Availability
Clone
50-6 (See other available formats)
Regulatory Status
RUO
Other Names
Platelet-endothelial tetraspan antigen 3, GP27, Membrane glycoprotein SFA-1, Tetraspanin-24, Tspan-24
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
50-6_APC_092210
Human peripheral blood platelets stained with anti-human purified CD151 (clone 50-6) conjugated with APC
  • 50-6_APC_092210
    Human peripheral blood platelets stained with anti-human purified CD151 (clone 50-6) conjugated with APC
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Cat # Size Price Quantity Check Availability Save
350405 25 tests 106€
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350406 100 tests 238€
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Description

CD151, also known as PETA-3, is a 29 kD protein member of the tetraspanin family (TM4SF). As other members in the family, PETA-3 is composed of two extracellular loops (one larger than the other), four transmembrane domains, and two cytoplasmic tails. Also, as other members in the family, CD151 is involved in cell adhesion, migration, and tumor cell metastasis. PETA-3 is expressed by many different cell types such as immature hematopoietic cells, megakaryocytes, platelets, keratinocytes, epithelial cells, muscle cells, Schwann cells, and vascular endothelium. On the cell surface, PETA-3 associates with CD9, CD181, and the integrins α3β1, α5β1, and α6β4.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human epidermoid carcinoma cell line HEp-3
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: in vivo inhibition of metastasis of HEp-3 cells1, Western blotting1, immunocytochemical staining of HEp-3 cells1, and CD151-transfected COS cells fixed with 0.25% glutaraldehyde.

Application References
  1. Testa JE, et al. 1999. Cancer Res. 59:3812. (Block, ICC, WB)
RRID
AB_10661726 (BioLegend Cat. No. 350405)
AB_10661727 (BioLegend Cat. No. 350406)

Antigen Details

Structure
Member of the tetraspanin family (TM4SF), 29 kD protein, consist of two extracellular loop, four transmembrane domains and two cytoplasmic tails
Distribution

Immature hematopoietic cells, megakaryocytes, platelets, keratinocytes, epithelial cells, muscle cells, Schwann cells, vascular endothelium

Function
Cell adhesion, migration
Interaction
CD9, CD181, integrins α3β1, α5β1 and α6β4
Cell Type
Epithelial cells, Hematopoietic stem and progenitors, Megakaryocytes, Mesenchymal Stem Cells, Platelets
Biology Area
Angiogenesis, Cell Adhesion, Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology, Stem Cells
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Zöller M. 2009. Nat. Rev. Cancer 9:40.
2. Yañez-Mó M, et al. 2008. Blood 112:3217.
3. Nishiuchi R, et al. 2005. Proc. Natl. Acad. Sci. USA 102:1939.

Gene ID
977 View all products for this Gene ID
UniProt
View information about CD151 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11-30-2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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