- D2-40 (See other available formats)
- Regulatory Status
- Other Names
- Podoplanin, T1-alpha, hT1alpha-1, hT1alpha-2, PA2.26 antigen, glycoprotein 36, lung type-I cell membrane-associated glycoprotein (T1A-2)
- Mouse IgG1, κ
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- Product Citations
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Podoplanin is expressed by a variety of normal cells, which include breast and prostate myopepithelial cells, follicular dendritic cells, basal keratinocytes of the skin and cervix (focal), type I pneumocytes, ependymal cells, and fetal cerebral germinal matrix cells. Podoplanin is a marker of lymphatic differentiation because it is expressed by normal human lymphatic endothelium, but not by vascular endothelium. It is diagnostically a useful marker for the evaluation of a variety of neoplasms, including Kaposi sarcoma mesothelioma, testicular germ cell tumors, and cutanneous sebaceous neoplasms.Product Details
- Antibody Type
- Host Species
- M2A protein derived from human germ cell tumors.
- Phosphate-buffered solution, pH 7.2.
- The antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
WB - Verified
ELISA Detection, ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemistry. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.5 - 5.0 μg/ml is suggested. For Western blotting, the suggested use of this reagent is 2.0 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: ELISA Detection5 and immunocytochemistry4.
- Application References
- Hamanaka T, et al. 2011. Invest. Ophthalmol. Vis. Sci. 52:8849. (IHC-P)
- Choi WW, et al. 2005. Mod. Pathol. 18:143. (IHC-P)
- Chu AY, et al. 2005. Mod. Pathol. 18:105. (IHC-P) PubMed
- Yoon C, et al. 2008. Blood 112:1129. (ICC) PubMed
- Schacht V, et al. 2005. American Journal of Pathology 166:913. (ELISA Detection, WB) PubMed
- Marks A, et al. 1999. British Journal of Cancer 80:569.
- Product Citations
AB_2565819 (BioLegend Cat. No. 916605)
AB_2565820 (BioLegend Cat. No. 916606)
- 35 kD.
Membrane and plasma membrane.
- May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport and does not function as a water channel or as a regulator of aquaporin-type water channels.
- Cytoskeletal signaling.
- Biology Area
- Cancer Biomarkers, Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Gene ID
- 10630 View all products for this Gene ID
- View information about Podoplanin on UniProt.org
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