APC anti-mouse CD32 (Fcgr2) Antibody

Pricing & Availability
Clone
S17012B (See other available formats)
Regulatory Status
RUO
Other Names
Fcr-2, Fcr-3, Ly-17, LyM-1, Lym-1, fcRII, FcgRII, fcgr2b
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
S17012B_APC_CD32_Antibody_070920.png
C57BL/6 mouse splenocytes were stained with anti-mouse CD19 PE and anti-mouse CD32 APC (clone S17012B) (top) or rat IgG2b, κ isotype APC control (right).
  • S17012B_APC_CD32_Antibody_070920.png
    C57BL/6 mouse splenocytes were stained with anti-mouse CD19 PE and anti-mouse CD32 APC (clone S17012B) (top) or rat IgG2b, κ isotype APC control (right).
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156405 25 µg 71€
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156406 100 µg 229€
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Description

CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein, member of the immunoglobulin superfamily. The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity, but binds immune complexes efficiently. CD32 can mediate phagocytosis of immune complexes and modulate cell activation. CD32 is expressed by Macrophages, neutrophils, mast cells and B cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CD32 transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
RRID
AB_2876523 (BioLegend Cat. No. 156405)
AB_2876523 (BioLegend Cat. No. 156406)

Antigen Details

Structure
40 kD transmembrane glycoprotein, member of the immunoglobulin superfamily; extracellular region consists of two Ig C-type domains.
Distribution

Macrophages, neutrophils, mast cells and B cells.

Function
Mediates phagocytosis of immune complexes, modulates cell activation.
Ligand/Receptor
Binds Fc from monomeric IgG with low affinity, binds immune complexes efficiently.
Cell Type
B cells, Macrophages, Mast cells, Neutrophils
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References
  1. Negishi-Koga T, et al. 2015. Nat Commun. 6:6637
  2. Yamada DH, et al. 2015. Immunity. 42:379
  3. Clatworthy MR, et al. 2014. Nat Med. 20:1458
  4. Li F and Ravetch JV. 2011. Science. 333:1030
  5. Xiang Z, et al. 2007. Nat Immunol. 8:419
Gene ID
14130 View all products for this Gene ID
UniProt
View information about CD32 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 07/08/2020

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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