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PE/Fire™ 640 anti-human CD305 (LAIR1) Antibody

Pricing & Availability
Clone
NKTA255 (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
LAIR-1 (Leukocyte-associated Ig-like receptor 1)
Isotype
Mouse IgG1
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Product Citations
publications
NKTA255_PEFire640_CD305_Antibody_032624
Human peripheral blood lymphocytes were stained with anti-human CD4 (clone RPA-T4) FITC and anti-human CD305 (LAIR1) (clone NKTA255) PE/Fire™ 640 (left) or mouse IgG1, κ PE/Fire™ 640 isotype control (right).
  • NKTA255_PEFire640_CD305_Antibody_032624
    Human peripheral blood lymphocytes were stained with anti-human CD4 (clone RPA-T4) FITC and anti-human CD305 (LAIR1) (clone NKTA255) PE/Fire™ 640 (left) or mouse IgG1, κ PE/Fire™ 640 isotype control (right).
Compare all formats See PE/Fire™ 640 spectral data
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342809 25 tests $176
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342810 100 tests $382
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Description

CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Fire™ 640 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

* PE/Fire™ 640 has a maximum excitation of 566 nm and a maximum emission of 639 nm.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Poggi A, et al. 1995. Eur. J. Immunol. 25:369

Antigen Details

Structure
40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
Distribution

NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells

Function
Inhibition of cell cytotoxicity, cell activation, proliferation and differentiation
Ligand/Receptor
collagens
Cell Type
B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
Biology Area
Immunology, Inhibitory Molecules, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Meyaard L, et al. 2008. J. Leukoc. Biol. 83:799
2. Lebbink RJ, et al. 2006. J. Exp. Med. 203:1419

Gene ID
3903 View all products for this Gene ID
UniProt
View information about CD305 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 03/07/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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