Purified anti-mouse CD262 (DR5, TRAIL-R2) Antibody

Pricing & Availability
Clone
W18111A (See other available formats)
Regulatory Status
RUO
Other Names
DR5, TRAIL-R2, TNFRS10B, TRICK2, KILLER
Isotype
Rat IgG2a, λ
Ave. Rating
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Product Citations
publications
W18111A_PURE_CD262_Antibody_031324
Mouse DR5 transfected cells were stained with purified anti-mouse CD262 (DR5, TRAIL-R2) (clone W18111A) (filled histogram), or purified rat IgG2a, λ isotype control (open histogram), followed by anti-rat IgG PE.
  • W18111A_PURE_CD262_Antibody_031324
    Mouse DR5 transfected cells were stained with purified anti-mouse CD262 (DR5, TRAIL-R2) (clone W18111A) (filled histogram), or purified rat IgG2a, λ isotype control (open histogram), followed by anti-rat IgG PE.
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118702 100 µg 240€
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Description

CD262, also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER, is a 55 kD protein. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- κB and induces apoptosis. DR5 is induced by wild-type p53.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse DR5-Ig fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_3097171 (BioLegend Cat. No. 118702)

Antigen Details

Structure
Type I transmembrane protein, TNF receptor superfamily member, homotrimer, predicted molecular weight 55 kD
Distribution

Widely expressed in normal tissues and some tumor cell lines. Expression regulated by the tumor suppressor p53.

Function
Binds to TRAIL, activates NF-κB, induces apoptosis. May be involved in the regulation of tumor metastases.
Interaction
The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP.
Ligand/Receptor
TRAIL (CD253); cytoplasmic domain interacts with TRADD and RIP
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References
  1. Wu GS, et al. 1999. Cancer Res. 59:2770-5.
  2. Walczak H, et al. 1997. EMBO J. 16:5386-97.
  3. Shigeno M, et al. 2003. Oncogene. 22:1653-62.
  4. LaVallee T, et al. 2003. Cancer Res. 63:468-75.
  5. Nimmanapalli R, et al. 2001. Cancer Res. 61:759-63.
Gene ID
21933 View all products for this Gene ID
UniProt
View information about CD262 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/24/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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