Purified anti-human LAP Recombinant Antibody

Pricing & Availability
QA20A25 (See other available formats)
Regulatory Status
Other Names
Latency Associated Peptide (LAP), Transforming growth factor beta 1 (TGF-b1), TGFB1, DPD1
Mouse IgG1, κ
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Product Citations
Human LAP transfected cells were stained with purified anti-human LAP (TGF-β1) (clone QA20A25) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG biotin and Streptavidin-APC.
  • QA20A25_PURE_LAP_RECOM_Antibody_112221.png
    Human LAP transfected cells were stained with purified anti-human LAP (TGF-β1) (clone QA20A25) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by anti-mouse IgG biotin and Streptavidin-APC.
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364402 100 µg 146€
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TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many types of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide), in which LAP noncovalently associates with the dimeric mature TGF-β to prevent its activity. TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8, and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in the regulation of the development of Treg, Th17, and Th9 cells. A recent study has shown that LAP is an activated Treg surface marker.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
The antibody was purified by affinity chromatography.
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

AB_2910406 (BioLegend Cat. No. 364402)

Antigen Details

About 400 amino acids, N-terminal signal peptide is required for secretion from a cell, a pro-region (LAP) and C-terminal region that becomes the mature TGF-β molecule following its release from the pro-region by proteolytic cleavage.

Ubiquitously expressed by many kinds of cells 

Multifunctional cytokine, regulates cells proliferation, and differentiation
TGF-βRI, -RII, -RIII, CD105, LTBP, integrins
Cell Type
B cells, Dendritic cells, T cells, Tregs
Biology Area
Adaptive Immunity, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Inhibitory Molecules, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
Cytokine/Chemokine Receptors, Growth Factors
Antigen References
  1. Yi JJ, et al. 2010. Cell 142:144.
  2. Tran DQ, et al. 2009. Blood 113:5125.
  3. Lu M, et al. 2002. J. Cell. Sci. 115:4641.
  4. Khalil N. 1999. Microbes Infect. 1:1255. 
Gene ID
7040 View all products for this Gene ID
View information about LAP on UniProt.org

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Go To Top Version: 1    Revision Date: 11/22/2021

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This data display is provided for general comparisons between formats.
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