ELISA MAX™ Deluxe Set Human RAGE ELISA Kit

Pricing & Availability
Regulatory Status
RUO
Other Names
Advanced glycosylation end product-specific receptor
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ELISA-MAX_Deluxe_Human_RAGE_071323
  • ELISA-MAX_Deluxe_Human_RAGE_071323
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449904 5 plates 395 CHF
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Description

Receptor for advanced glycation end products is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface molecules. It can be found in adult lung and skin tissue but low levels are found in other tissue types such as endothelia, cardio myocytes, neutrophils, macrophages, lymphocytes, dendritic cells, and the central nervous system. Due to the multi-ligand nature of RAGE, the receptor is involved in activation of many cell signal pathways such as ERK1/2, p38, SHPK/JNK MAP Kinases, rho GTPases, phosphoinositol-3-kinase (PI3K), and JAK/STAT. It has been found to be involved in pathogenesis and complications that are age related such as diabetes and Alzheimer’s, as well as cellular processes such as inflammation, apoptosis, autophagy, and proliferation.

Product Details
Technical Data Sheet (pdf)

Kit Contents

Kit Contents
  • Human RAGE ELISA MAX™ Capture Antibody (200X)
  • Human RAGE ELISA MAX™ Detection Antibody (200X)
  • Human RAGE Standard
  • Avidin-HRP (1,000X)
  • Substrate Solution D
  • Coating Buffer B (5X)
  • Blocking Buffer A (2X)
  • Assay Diluent D
  • Assay Diluent B (5X)

Product Details

Verified Reactivity
Human
Application

ELISA

 
As a part of BioLegend's efforts to go green, each new lot of the ELISA MAX™ sets will include a summarized version of its manual. Click here for more information.
Sensitivity
41.28 ± 39.7 pg/mL
Standard Range
78.1 - 5000 pg/mL
Materials Not Included
  • Microwell plates: BioLegend Cat. No. 423501 is recommended
  • Wash Buffer: BioLegend Cat. No. 421601 is recommended, or PBS + 0.05% Tween-20
  • Stop Solution: BioLegend Cat. No. 423001 is recommended, or acid solution, e.g. 2N H2SO4
  • Plate Sealers: BioLegend Cat. No. 423601 is recommended
  • PBS (Phosphate-Buffered Saline): 8.0 g NaCl, 1.16 g Na2HPO4, 0.2 g KH2PO4, 0.2 g KCl, add deionized water to 1 L; pH to 7.4, 0.2 μm filtered
  • Deionized (DI) water 
  • A microplate reader capable of measuring absorbance at 450 nm
  • Adjustable pipettes to measure volumes ranging from 2 μL to 1 mL
  • Wash bottle or automated microplate washer
  • Log-Log graph paper or software for data analysis
  • Tubes to prepare standard dilutions
  • Timer  

Antigen Details

Cell Type
Dendritic cells, Endothelial cells, Lymphocytes, Macrophages, Neutrophils
Biology Area
Cell Proliferation and Viability, COVID-19, Signal Transduction
Molecular Family
Soluble Receptors
Gene ID
NA
UniProt
View information about RAGE on UniProt.org

Related FAQs

Do the ELISA MAX™ Deluxe Sets come with plates?

No, ELISA MAX™ Deluxe Sets do not come with plates. Coating Buffer and Assay Diluent (for blocking and dilutions) are included in these sets. Plates can be ordered separately (Cat No. 423501), and instructions for coating the plates are in the sets’ product manuals.

Go To Top Version: 1    Revision Date: 07.13.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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