Purified anti-mouse CD163 Recombinant Antibody

Pricing & Availability
Clone
QA20A94 (See other available formats)
Regulatory Status
RUO
Other Names
M130, MM130, SCARI1
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
QA20A94_PURE_CD163_RECOM_Antibody_070822
C57BL/6 bone marrow cells were stained with anti-mouse CD11b APC and purified anti-mouse CD163 recombinant (clone QA20A94) (left), or purified rat IgG1, κ isotype control (right), followed by PE goat anti-rat IgG.
  • QA20A94_PURE_CD163_RECOM_Antibody_070822
    C57BL/6 bone marrow cells were stained with anti-mouse CD11b APC and purified anti-mouse CD163 recombinant (clone QA20A94) (left), or purified rat IgG1, κ isotype control (right), followed by PE goat anti-rat IgG.
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111802 100 µg $315
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Description

CD163, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen, is a member of the group B scavenger receptor cysteine-rich superfamily. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2936520 (BioLegend Cat. No. 111802)

Antigen Details

Structure
Type 1 transmembrane glycoprotein, 134 kD (non-reduced)/155 kD (reduced) glycoprotein
Distribution

Macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells

Function
Binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages
Cell Type
Dendritic cells, Hematopoietic stem and progenitors, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Jiang L, et al. 2020. Cell. 183:1219-1233.e18.  
  2. Harb H, et al. 2021. Immunity. 54:1186-1199.e7.  
Gene ID
93671 View all products for this Gene ID
UniProt
View information about CD163 on UniProt.org
Go To Top Version: 1    Revision Date: 07/08/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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