- RM2-5 (See other available formats)
- Regulatory Status
- Other Names
- LFA-2, T11, Ly-37, SRBC-R
- Rat IgG2b, λ
- Ave. Rating
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- Product Citations
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CD2 is a 45-58 kD type I transmembrane glycoprotein, also known as LFA-2, T11 or Ly-37. It is a member of the Ig superfamily. Mouse CD2 is primarily expressed on T cells, B cells, thymocytes and NK cells. It is a ligand for CD48 and is involved in T cell activation and differentiation.Product Details
- Antibody Type
- Host Species
- BALB/c mouse thymocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP, Block, Costim - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: in vitro blocking of CD2-mediated cell-cell adhesion and inhibition of T cell activation1, blocking of T cell A.I.C.D.2, immunoprecipitation3, and co-induction of thymocyte maturation4. The RM2-5 antibody can block CD2-mediated cell-cell adhesion. The Ultra-LEAF™ Purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 100118 and 100119).
(PubMed link indicates BioLegend citation)
- Nakamura T, et al. 1990. J. Immunol. 145:3628. (Block)
- Ayroldi E, et al. 1997. Blood 89:3717. (Block)
- Criado G, et al. 1996. Eur. J. Immunol. 26:1228. (IP)
- Cibotti R, et al. 1997. Immunity 6:245. (Costim)
- Product Citations
AB_312649 (BioLegend Cat. No. 100102)
- Ig superfamily, 45-58 kD
T cells, thymocytes, NK cells, B cells
- T cell activation, adhesion
- CD48, lck
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Davis SJ, et al. 1996. Immunol. Today 17:177.
3. Bierer BE, et al. 1989. Annu. Rev. Immunol. 7:579.
- Gene ID
- 12481 View all products for this Gene ID
- View information about CD2 on UniProt.org
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