- 2.11 (See other available formats)
- Regulatory Status
- Other Names
- T cell receptor Vgamma 1.1, TCR Vγ1, TCR Cr4
- Armenian hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- T3.13.1 T-cell hybridoma cell line
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Pacific Blue™ under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Violet Laser (405 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation1.
(PubMed link indicates BioLegend citation)
- Pereira P, et al. 1995. J. Exp. Med. 182:1921. (IP)
- Pereira P and Boucontet L. 2004. J. Immunol. 173:3261. (FC)
- Pereira P, et al. 1996. Intl. Immunol. 8:83. (FC)
AB_2750498 (BioLegend Cat. No. 141109)
AB_2750499 (BioLegend Cat. No. 141110)
- Ig superfamily
Subset of γ/δ T-cells
- Antigen recognition
- Cell Type
- T cells
- Biology Area
- Immunology, Adaptive Immunity
- Molecular Family
- Antigen References
1. Pereira P, et al. 1995. J. Exp. Med. 182:1921.
2. Grigoriadou K, et al. 2002. J. Immunol. 169:3736.
- Gene ID
- 110067 View all products for this Gene ID
- View information about TCR V gamma1.1 on UniProt.org
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