- 330-AJ (See other available formats)
- Regulatory Status
- Other Names
- SLAM family receptor, SLAMF6, TCOM, SF2000, KALI, SF-3, NTBA, NTB-A, NK-T-B antigen
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Mouse Ly108, also known as SLAMF6 and NTB-A (NK cell, T cell, B cell antigen), is one of the members in The Signaling Lymphocytic Activation Molecule (SLAM) family of immune receptors. It is expressed on T cells, B cells, macrophages, dendritic cells, NK cells, and granulocytes. Homophilic interaction of Ly108 is involved in augmenting cytotoxicity of NK cells. Ly108 has been shown to function on NK cells by augmenting cytotoxicity. It was reported that Ly108 plays an important role in CD4+ T cell responses and innate immunity to bacteria and parasites. In a mouse with a targeted disruption of the Ly108 gene, CD4+ T cells and innate responses are defective. SLAM family of receptors has been implicated in the pathophysiology of autoimmunity. For instance, Ly108 is strongly linked to lupus susceptibility in mice. Ly108 may censor self-reactive B cells as a potential regulator of tolerance checkpoints, safeguarding against autoimmunity. Therefore, Ly108 serves as a regulator of both innate and adaptive immune responses.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* Pacific Blue™ has a maximum emission of 455 nm when it is excited at 405 nm. Prior to using Pacific Blue™ conjugate for flow cytometric analysis, please verify your flow cytometer's capability of exciting and detecting the fluorochrome.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Violet Laser (405 nm)
(PubMed link indicates BioLegend citation)
- Fu GF, et al. 2012. Int Immunol. 24:197. PubMed.
- Product Citations
AB_2188093 (BioLegend Cat. No. 134608)
- A glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptor. It is a novel member of the CD2 subfamily of the Ig superfamily.
Expressed on T cells, B cells, macrophages, dendritic cells, NK cells, and granulocytes.
- Play an important role in CD4+ T cell responses, innate immunity to bacteria and parasites, and NK cell function.
- Cell Type
- B cells, Dendritic cells, Granulocytes, Macrophages, NK cells, T cells
- Biology Area
- Immunology, Innate Immunity
- Antigen References
1. Howie D, et al. 2005. J. Immunology. 174 (10):5931
2 Kumar KR, et al. 2006. Science. 312(5780):1665
3. Zhong MC, et al. 2008. J. Biol. Chem. 283 (28):19255
4. Peck SR et al. 2000. Immunogenetics. 52:63
- Gene ID
- 30925 View all products for this Gene ID
- View information about Ly108 on UniProt.org
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