FITC anti-mouse CD79b (Igβ) Antibody

Pricing & Availability
Clone
HM79-12 (See other available formats)
Regulatory Status
RUO
Other Names
Ig β chain
Isotype
Armenian Hamster IgG
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Product Citations
publications
HM79-12_FITC_071009.jpg
C57BL/6 splenocytes stained with HM79-12 FITC
  • HM79-12_FITC_071009.jpg
    C57BL/6 splenocytes stained with HM79-12 FITC
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132805 50 µg 84,00€
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132806 200 µg 220,00€
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Description

Mouse CD79b (Igβ chain) is a 35-40kD transmembrane protein that forms a heterodimer with CD79a (30-35 kD, Ig α chain). The CD79b and CD79a hererodimers are associated with surface IgM to form the B-cell receptor (BCR) that is necessary for signal transduction via the BCR in mature B cells. CD79b participates in the signal transduction involved in development of B cells as well. It was reported that association between CD79b/CD79a with IgM is essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion. Igβ knockout mice had a complete block in B cell development at the immature CD43+B220+ stage. The HM79b-12 clone reacts with an extracellular epitope of CD79b or Igβ.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser
Blue Laser (488 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Gong S, et al. 1996. Science. 272:411.
  2. Nagata K, et al. 1997. Immunity 7:559.
  3. Papavasiliou F, et al. 1995. 268:408.
Product Citations
  1. Stewart I et al. 2018. Immunity. 49(3):477-489 . PubMed
  2. Shehata L, et al. 2019. Cell Rep. 28:3300. PubMed
  3. Blanc P, et al. 2016. Nat Commun. 7:13600. PubMed
RRID
AB_2244530 (BioLegend Cat. No. 132805)
AB_2075882 (BioLegend Cat. No. 132806)

Antigen Details

Structure
A 35-40 kD transmembrane protein which forms an 80-90 kD heterodimer with CD79a.
Distribution

CD79b expression is restricted to pro-B cell, pre-B cell, and mature B cells.

Ligand/Receptor
CD79a/CD79b heterodimers are associated with surface IgM to form B cell receptor complex (BCR) to recognize specific antigen.
Cell Type
B cells
Biology Area
Immunology
Molecular Family
CD Molecules
Gene ID
15985 View all products for this Gene ID
UniProt
View information about CD79b on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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