- SS12B (See other available formats)
- Regulatory Status
- Other Names
- NR4, CT19
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD213a1, also known as IL-13Rα1, is a subunit of the IL-13R complex. It can heterodimerize with IL-4R and bind IL-13 with high affinity. IL-13Rα1 by itself binds IL-13 with low affinity compared to IL-13Rα2. It is a 48.7 kD, single pass type I membrane protein. It is expressed at low levels on myeloid cells and on activated T and B cells and Th17 cells. It interacts with TYK2 and may lead to activation of JAK1, STAT3, and STAT6 that is induced by IL-13 and IL-4. It has been implicated to have a role in asthma and allergic responses.Product Details
- Antibody Type
- Host Species
- Recombinant extracellular domain of human IL-13 receptor α1 chain
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Product Citations
AB_2562625 (BioLegend Cat. No. 360405)
AB_2562626 (BioLegend Cat. No. 360406)
- Single-pass type I membrane protein 48.7 kD; forms a heterodimer with IL-4R
Expressed at low levels on myeloid cells; also expressed on activated T and B cells, Th17 cells
- Functional receptor for IL-13
- Interacts with TYK2 and can lead to downstream activation of JAK1, STAT3, and STAT6
- Cell Type
- B cells, T cells, Th17
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Aman MJ, et al. 1996. J. Biol. Chem. 271:29265.
2. Osawa M, et al. 2000. Immunogenetics. 51:974.
3. Arima K, et al. 2005. J. Biol. Chem. 280:24915.
4. LaPorte SL, et al. 2008. Cell. 132:259.
5. Newcomb DC, et al. 2011. J. Allerg. Clin. Immunol. 127:1006.
- Gene ID
- 3597 View all products for this Gene ID
- View information about CD213a1 on UniProt.org
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