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Ultra-LEAF™ Purified anti-human IL-11 Antibody

Pricing & Availability
Clone
A15128A (See other available formats)
Regulatory Status
RUO
Other Names
Adipogenesis Inhibitory Factor (AGIF)
Isotype
Mouse IgG2a, κ
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Product Citations
publications
Human_IL-11_ULEAF_Pure_Antibody_BA_012717
Recombinant human IL-11 induces the proliferation of 7TD1 cells in a dose dependent manner (black circles). Ultra-LEAFâ„¢ purified anti-human IL-11 antibody (clone A15128A, purple circles) neutralizes the 7TD1 cell proliferation induced by recombinant human IL-11 (100 ng/mL). The ND50 = 0.2 – 0.8 µg/mL.
  • Human_IL-11_ULEAF_Pure_Antibody_BA_012717
    Recombinant human IL-11 induces the proliferation of 7TD1 cells in a dose dependent manner (black circles). Ultra-LEAFâ„¢ purified anti-human IL-11 antibody (clone A15128A, purple circles) neutralizes the 7TD1 cell proliferation induced by recombinant human IL-11 (100 ng/mL). The ND50 = 0.2 – 0.8 µg/mL.
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694203 100 µg $270
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694204 1 mg $715
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Description

IL-11, a member of the IL-6 family of cytokines, exerts a wide range of biological effects on various cell types including hematopoietic cells, hepatocytes, adipocytes, neurons, and osteoblasts. IL-11 works synergistically with other growth factors including SCF, IL-4, IL-3, IL-7, IL-12, IL-13, and GM-CSF to stimulate the proliferation of cells from several hematopoietic lineages. Binding of IL-11 to IL-11 receptor (IL-11R) induces membrane bound gp130 homodimerization and triggers STAT3 phosphorylation by JAK. IL-11 shares the common receptor subunit gp130 with IL-6, IL-27, LIF, OSM, CNTF, CT-1, CLC, and NP. Female mice deficient in IL-11R revealed an important role for IL-11 in embryonic implantation. In addition, IL-11 shows anti-inflammatory activity in models of inflammatory bowel disease, chemotherapy induced oral mucositis, and inflammatory arthritis. IL-11 and IL-13 are highly expressed in asthmatic airways (Th2 response), and IL-11 can inhibit Th1 responses and inhibits the production of Th1 cytokines such as IL-12 and shifts inflammation in Th2 direction. Elevated IL-11 expression is associated with tumor grade and invasion in gastric cancer. Recombinant human IL-11 has been clinically approved to improve platelet recovery after chemotherapy-induced thrombocytopenia.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human IL-11.
Formulation
Phosphate-buffered solution, pH 7.2.
Preparation
The antibody was purified by affinity chromatography.
Concentration
The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

Neut - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by neutralizing activity. The ND50 is 0.2 – 0.8 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2650725 (BioLegend Cat. No. 694203)
AB_2650726 (BioLegend Cat. No. 694204)

Antigen Details

Structure
Cytokine
Distribution

Epithelial, endothelial, keratinocytes, stromal, neuronal, fibroblasts, osteoclasts, and bone marrow stromal cells.

Function
IL-11 plays important roles in hemopoiesis, thrombopoiesis, megakaryocytopoiesis, and bone resorption; It regulates macrophage differentiation and confers mucosal protection after chemotherapy and radiation therapy.
Interaction
Hematopoietic cells, hepatocytes, adipocytes, neurons, osteoblasts, fibroblasts, and gastrointestinal epithelial cells.
Ligand/Receptor
Membrane bound or soluble IL-11Rα heterodimerize with gp130β.
Cell Type
Endothelial cells, Epithelial cells, Fibroblasts, Osteoclasts
Biology Area
Cell Biology
Molecular Family
Cytokines/Chemokines
Antigen References

1. Putoczki T and Ernst M. 2010. J. Leuko. Biol. 88 1109.
2. Wilde MI and Faulds D. 1998. BioDrugs 10:159.
3. Barton VA, et al. 2000. J. Biol. Chem. 275:36197.
4. Robb L, et al. 1998. Nat. Med. 4:303.
5. Lemoli RM, et al. 1995. Br. J. Haematol. 91:319.
6. Elias JA, et al. 1994. J. Biol. Chem. 269:22261.
7. Chen Q, et al. 2005. J. Immunol. 174:2305.

Gene ID
3589 View all products for this Gene ID
UniProt
View information about IL-11 on UniProt.org

Related FAQs

Do you guarantee that your antibodies are totally pathogen free?

BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.

Does BioLegend test each Ultra-LEAF™ antibody by functional assay?

No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.

Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?

No, BioLegend does not test for pathogens in-house unless otherwise indicated.  However, we can recommend an outside vendor to perform this testing as needed.

Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?

We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.

Go To Top Version: 1    Revision Date: 01/30/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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