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- Clone
- A17002B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- V-Set Immunoregulatory Receptor (VSIR), B7H5, GI24, B7-H5, Dies1, PD-1H, SISP1, VISTA, PP2135, C10orf54, DD1alpha
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes were stained with purified anti-human VISTA (PD-1H) (clone A17002B) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram). Cells were then stained with goat anti-mouse IgG PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 378102 | 100 µg | $340 | ||||
VISTA (V-domain Ig suppressor of T cell activation), also known as PD-1H, is a type I transmembrane protein with a single extracellular IgV domain. VISTA is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It was reported that in certain tumor environment, there is low-pH dependent interaction between VISTA and PSGL1. However, the physiological binding partner for VISTA and the mechanism of its action are not clearly understood. VISTA is considered as a checkpoint regulator and a promising target for cancer immunotherapy.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human VISTA protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC – Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2910435 (BioLegend Cat. No. 378102)
Antigen Details
- Structure
- Ig V-domain like
- Distribution
-
Hematopoietic cells, monocytes, macrophages, dendritic cell, granulocytes, subsets of T cells
- Function
- Suppressing T cell activation
- Cell Type
- Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes, T cells
- Biology Area
- Immunology, Inhibitory Molecules
- Antigen References
-
- Wang Li, et al. 2011. J Exp Med. 208:577-92.
- Nowak EC, et al. 2017. Immunol Rev. 276:66-79.
- Flies DB, et al. 2014. J Clin Invest. 124:1966-75.
- Gene ID
- 64115 View all products for this Gene ID
- UniProt
- View information about VISTA on UniProt.org
Related FAQs
Other Formats
View All VISTA Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human VISTA (PD-1H) | A17002B | FC |
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Purified anti-human VISTA (PD-1H)
Human peripheral blood monocytes were stained with purified ...
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