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APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
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123115 25 µg 40€
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123116 100 µg 115€
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  2. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  3. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  4. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  5. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  6. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  7. Yang D, et al. 2022. Cell. 185:1905. PubMed
  8. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  9. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  10. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  11. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  12. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  13. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  14. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  15. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  16. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  17. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  18. He R, et al. 2021. J Immunol. 206:2353. PubMed
  19. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  20. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  21. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  22. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  23. He F, et al. 2021. J Exp Med. 218:. PubMed
  24. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  25. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  26. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  27. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  28. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  29. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  30. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  31. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  32. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  33. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  34. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  35. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  36. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  37. Kim SE, et al. 2019. Nutrients. 11. PubMed
  38. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  39. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  40. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  41. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  42. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  43. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  44. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  45. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  46. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  47. Dong L, et al. 2021. Cancer Cell. . PubMed
  48. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  49. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  50. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  51. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  52. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  53. Han J, et al. 2022. FEBS J. 289:417. PubMed
  54. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  55. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  56. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  57. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  58. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  59. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  60. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  61. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  62. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  63. Sun P, et al. 2015. J Hepatol. . PubMed
  64. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  65. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  66. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  67. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  68. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  69. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  70. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  71. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  72. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  73. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  74. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  75. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  76. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  77. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  78. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  79. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  80. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  81. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  82. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  83. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  84. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  85. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  86. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  87. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  88. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  89. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  90. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  91. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  92. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  93. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  94. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  95. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  96. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  97. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  98. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  99. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  100. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  101. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  102. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  103. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  104. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  105. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  106. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  107. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  108. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  109. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  110. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  111. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  112. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  113. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  114. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  115. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  116. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  117. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  118. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  119. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  120. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  121. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  122. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  123. Lv F, et al. 2022. iScience. 25:103639. PubMed
  124. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  125. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  126. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  127. Gao H, et al. 2021. Cells. 10:. PubMed
  128. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  129. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  130. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  131. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  132. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  133. Oatley J, et al. 2009. Development. 136:1191. PubMed
  134. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  135. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  136. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  137. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  138. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  139. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  140. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  141. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  142. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  143. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  144. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  145. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  146. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  147. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  148. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  149. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  150. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  151. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  152. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  153. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  154. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  155. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  156. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  157. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  158. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  159. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  160. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  161. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  162. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  163. Yang Y, et al. 2022. Elife. 11:. PubMed
  164. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  165. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  166. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  167. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  168. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  169. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  170. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  171. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  172. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  173. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  174. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  175. Matundan H, et al. 2019. J Virol. 93. PubMed
  176. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  177. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  178. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  179. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  180. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  181. Lang V, et al. 2021. Elife. 10:. PubMed
  182. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  183. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  184. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  185. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  186. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  187. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  188. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  189. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  190. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  191. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  192. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  193. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  194. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  195. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  196. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  197. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  198. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  199. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  200. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  201. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  202. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  203. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  204. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  205. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  206. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  207. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  208. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  209. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  210. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  211. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  212. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  213. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  214. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  215. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  216. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  217. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  218. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  219. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  220. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  221. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  222. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  223. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  224. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  225. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  226. Calle P, et al. 2021. Cells. 10:. PubMed
  227. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  228. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  229. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  230. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  231. Deng W, et al. 2015. Clin Immunol. . PubMed
  232. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  233. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  234. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  235. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  236. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  237. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  238. Engblom C, et al. 2017. Science. 358:6367. PubMed
  239. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  240. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  241. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  242. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  243. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  244. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  245. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  246. Horsle B 2013. Development. 140:1517. PubMed
  247. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  248. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  249. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  250. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  251. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  252. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  253. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  254. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  255. Karki R, et al. 2020. bioRxiv. . PubMed
  256. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  257. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  258. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  259. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  260. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  261. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  262. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  263. Gu H, et al. 2021. Elife. 10:. PubMed
  264. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  265. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  266. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  267. Karki R, et al. 2021. Cell. 184:149. PubMed
  268. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  269. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  270. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  271. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  272. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  273. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  274. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  275. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  276. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  277. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  278. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  279. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  280. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  281. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  282. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  283. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  284. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  285. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  286. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  287. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  288. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  289. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  290. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  291. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  292. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  293. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  294. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  295. Liu SS, et al. 2021. Immunity. :. PubMed
  296. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  297. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  298. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  299. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  300. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  301. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  302. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  303. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  304. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  305. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  306. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  307. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  308. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  309. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  310. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  311. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  312. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  313. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  314. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  315. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  316. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  317. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  318. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  319. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  320. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  321. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  322. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  323. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  324. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  325. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  326. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  327. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  328. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  329. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  330. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
  331. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  332. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  333. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  334. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  335. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  336. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  337. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  338. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  339. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  340. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  341. Lalor R, et al. 2019. Nutrients. 11. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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