- W15136A (See other available formats)
- Regulatory Status
- Other Names
- Nuclear receptor subfamily 1 group D member 2, BD73, V-erbA-related protein 1-related (EAR-1r), Hs.37288, HZF2, Rev-erb alpha-related receptor (RVR), Rev-erb-beta
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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Nuclear receptor subfamily 1, group D, member 2 (NR1D2), also known as Rev-ErbA β, is a member of the nuclear hormone receptor family. This protein can modulate gene expression by directly binding to DNA response elements within the promotor of its target genes as either monomers or homodimers. NR1D2 is well known to function as a transcriptional repressor. By complexing with heme, NR1D2 coordinates circadian rhythm and controls lipid metabolism. NR1D2 can directly repress the expression of core clock components ARNTL/BMAL1 and CLOCK, to coordinate circadian rhythm. In addition, NR1D2 can regulate lipid and energy homeostasis in skeletal muscles via repression of lipid metabolism and myogenesis-related genes such as CD36, FABP, SCD1 and MSTN. It is also involved in the regulation of hepatic lipid metabolism through the suppression of APOC3 expression. Not only as a repressor, NR1D2 also acts as a transcriptional activator; it can activate the transcription of the sterol regulatory element-binding protein 1 (STEBF1) and the inflammatory mediator IL-6 in skeletal muscle. Alternatively spliced transcript variants of NR1D2 gene have been described.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial human NR1D2 recombinant protein (196-399 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2629653 (BioLegend Cat. No. 689402)
- 579 amino acids, predicted molecular weight of 65 kD. Contains two N-terminal zinc finger domains responsible for DNA binding.
- NR1D2 belongs to the nuclear hormone receptor family and acts as a transcriptional repressor. NR1D2 participates in the regulation of circadian rhythms and energy homeostasis.
- Forms a DNA-binding homodimer. Interacts with NCOA5, KAT5, HDAC1, and ZNHIT1.
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Transcription Factors
- Molecular Family
- Nuclear Markers, Steroid Receptors/Nuclear Receptors
- Antigen References
1. Cho H, et al. 2012. Nature 485:123.
2. Gupta N, Ragsdale SW. 2011. J. Biol. Chem. 286:4392.
3. Bois-Joyeux B, et al. 2000. DNA Cell Biol. 19:589-99.
4. Burke L, et al. 1996. Nucleic Acids Res. 24:3481.
5. Giambiagi N, et al. 1995. Biochem. Mol. Biol. Int. 37:1091.
6. Bonnelye E, et al. Cell Growth Differ. 5:1357.
- Gene ID
- 9975 View all products for this Gene ID
- View information about NR1D2 on UniProt.org
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