- 1D6-E3 (See other available formats)
- Regulatory Status
- Other Names
- Inosine Monophosphate Dehydrogenase 1, Inosine-5'-Monophosphate Dehydrogenase 1, IMP Dehydrogenase 1, IMPD1, IMP (Inosine Monophosphate) Dehydrogenase 1, Inosine Monophosphate Dehydrogenase Type 1, IMPDH 1
- Mouse IgG2b, κ
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- Product Citations
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Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) was initially identified as an oncogene in several human cancers. IMPDH1 catalyzes the conversion of inosine-5'-monophosphate (IMP) to xanthosine-5'-monophosphate (XMP) and is the first committed rate-limiting step in the de novo synthesis of GTP, and consequently it is involved in the regulation of cell growth. IMPDH1 is also part of the composition of the cytoplasmic rod and ring structures (RR) and is involved in maintaining cellular nucleotide pools needed for DNA and RNA synthesis.Product Details
- Human, Mouse, Hamster
- Antibody Type
- Host Species
- Full length IMPDH purified from a Chinese hamster V79 cell variant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IP, ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. For immunoprecipitation, the suggested use of this reagent is 2.5 µg/test. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone recognizes human, mouse and hamster IMPDH1 and is predicted to recognize the rodent orthologs. Clone is likely to cross react with IMPDH2.
For ICC testing, HeLa cells were fixed in 4% PFA and permeabilized with either Triton X-100 or methanol; both methods produced strong staining at 1 µg/mL.
- Product Citations
AB_2832890 (BioLegend Cat. No. 935201)
AB_2832891 (BioLegend Cat. No. 935202)
- IMPDH1 is an 514 aminoacid protein with a predicted molecular weight of 56 kD.
Localized to the cytosol filamentous rods and rings / Ubiquitously expressed
- Regulation of cell growth, and biosynthesis of de novo GTP
- Biology Area
- Cell Cycle/DNA Replication, Cell Proliferation and Viability, DNA Repair/Replication
- Antigen References
- Calise SJ, et al. 2015. Front Immunol. 6:41.
- Liao LX, et al. 2017. Proc Natl Acad Sci U S A. 29.
- Duan S, et al. 2018. J Exp Clin Cancer Res. 37:304.
- Zhao Y, et al. 2018. Biomarkers. 1:9.
- Carcamo WC, et al. 2011. PLoS One. 6.
- Xu Y, et al. 2017. Sci Rep. 7:745.
- Glesne DA, et al. 1991. Mol Cell Biol. 11:5417-25.
- Hager PW, et al. 1995. Biochem Pharmacol. 49:1323-9.
- Gene ID
- 3614 View all products for this Gene ID
- View information about IMPDH1 on UniProt.org
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