- 9F4 (See other available formats)
- Regulatory Status
- Other Names
- SMUCKLER (Spleen, mucin-containg, knock-out of lymphotoxin (LT)), TIMD4 (T-cell immunoglobulin and mucin domain containing 4)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th-1 and Th-2) cell-mediated immunity. Tim-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of Tim-1. This binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, Tim-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The Tim-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and is connected to Tim-1-triggered Th2 responsiveness.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Human TIM-4- IgV Fc, fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone 9F4 recognizes the FG loop of human Tim-41.
(PubMed link indicates BioLegend citation)
- Kobayashi N, et al. 2007. Immunity 27:927.
AB_11126746 (BioLegend Cat. No. 354002)
- Type 1 transmembrane glycoprotein and mucin domain containing protein 4.
Splenic CD14+, macrophages, immature DC.
- Tim-1 ligation to Tim-4 induces T cell proliferation, promotes cytokine production, and aids in the regulation of Th2 immunity.
- Phosphatiylserine is the receptor of Tim-4, and Tim-4 is a ligand of Tim-1.
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Antigen References
1. Kobayashi N, et al. 2007. Immunity 27:927.
2. Meyers JH, et al. 2005. Nat. Immunol. 6:455.
3. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
4. Shakhov AN, et al. 2004. Eur. J. Immunol. 34:494.
- Gene ID
- 91937 View all products for this Gene ID
- View information about Tim-4 on UniProt.org
|Purified anti-human Tim-4||9F4||FC|
|PE anti-human Tim-4||9F4||FC|
|APC anti-human Tim-4||9F4||FC|
|PE/Cyanine7 anti-human Tim-4||9F4||FC|
|TotalSeq™-A0428 anti-human Tim-4||9F4||PG|
|TotalSeq™-C0428 anti-human Tim-4||9F4||PG|
|TotalSeq™-B0428 anti-human Tim-4||9F4||PG|
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