Purified anti-human PlGF Antibody

Pricing & Availability
Clone
13C8 (See other available formats)
Regulatory Status
RUO
Other Names
PlGF, PLGF, Placental Growth Factor
Isotype
Mouse IgG1, λ
Ave. Rating
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Product Citations
publications
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534802 500 µg £373
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Description

Placental growth factor (PlGF) is a member of the PDGF/VEGF family of growth factors. Four alternatively-spliced isoforms have been identified: PlGF-1, PlGF-2, PlGF-3, and PlGF-4. All isoforms are expressed in placental tissues, with PlGF-2 being expressed specifically during early placental development. PlGF-1 and PlGF-3 are considered diffusible isoforms, while PlGF-2 and PlGF-4 each contain a unique heparin binding domain that may increase associations with cell membranes. In addition to placental tissues, PlGF is expressed in the microvasculature, bone marrow, umbilical vein endothelia, uterine keratinocytes, and NK cells. PlGF binds to both VEGF-R1 and neuropilin, but not VEGF-R2 and induces monocyte activation, migration, inflammatory cytokine production. PlGF plays a key role in maternal vascular function during pregnancy, with circulating levels reaching a peak mid-gestation. It can be used as a marker for pregnancy-associated hypertensive disorders such as pre-eclampsia.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant Protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA-C - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 1.0 - 4.0 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The purified 13C8 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated 24G3 antibody (Cat. No. 534904) as the detecting antibody.

RRID
AB_2894608 (BioLegend Cat. No. 534802)

Antigen Details

Structure
Homodimer
Distribution

Vascular endothelial cells, smooth muscle cells, keratinocytes, hematopoitic cells, retinal pigment epithelial cells, tumor cells, and cerebellar stroma cells.

Function
PlGF is an angiogenic factor and induces proliferation and migration of endothelial cells. It stimulates endothelial cells and synergistically amplifies the action of VEGF. Soluble VEGFR1 (sFLT1) can regulate the accessibility of PlGF.
Interaction
Endothelial cells, Macrophages, and trophoblats
Ligand/Receptor
VEGFR1 (FLT-1) and neuropilin 1 (Nrp1)
Cell Type
Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors
Antigen References
  1. Maglione D, et al. 1991. Proc Natl Acad Sci USA. 88:9267.
  2. Carmeliet P, et al. 2001. Nat Med. 7:575.
  3. Casalou C, et al. 2007. Leukemia. 21:1590.
  4. Marcellini M, et al. 2006. Am J Pathol. 169:643.
  5. Yao J, et al. 2011. Proc Natl Acad Sci USA. 108:11590.
  6. Cai J, et al. 2011. PLoS One. 6:e18076.
  7. Sibiude J, et al. 2012. PLoS One. 7:e50208.
  8. Snuderl M, et al. 2013. Cell. 152:1065.
Gene ID
5228 View all products for this Gene ID
UniProt
View information about PlGF on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12/14/2018

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

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