- VI-PL2 (See other available formats)
- Regulatory Status
- Other Names
- Integrin β3, gpIIIa
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.Product Details
- Verified Reactivity
- Human, Cynomolgus, Rhesus
- Reported Reactivity
- African Green, Baboon
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
- The antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
CyTOF® - Verified
- Recommended Usage
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
- Application Notes
Additional reported applications (for the relevant formats) include: Western blotting and immunohistochemical staining of frozen tissue sections.
- Additional Product Notes
Maxpar® is a registered trademark of Standard BioTools Inc.
(PubMed link indicates BioLegend citation)
- Davies J, et al. 1989. J. Cell Biol. 109:1817.
- Roberts M, et al. 2004. Mol. Cell. Biol. 24:1505.
- Ciarlet M, et al. 2002. J. Virol. 76:1109.
AB_2562833 (BioLegend Cat. No. 336413)
- Type I integral glycoprotein, integrin family, associates with CD41 (gpIIb) forming CD41/CD61 complex or with CD51 (integrin αV) forming CD51/CD61 complex, 90 kD
CD41/CD61 complex is expressed on platelets and megakaryocytes; CD51/CD61 complex is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells
- Adhesion, platelet activation and aggregation
- Fibronectin, vitronectin, vWF
- Cell Type
- Fibroblasts, Megakaryocytes, Osteoclasts, Platelets
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules: The CD Markers.
- Gene ID
- 3690 View all products for this Gene ID
- View information about CD61 on UniProt.org
- Can I obtain CyTOF data related to your Maxpar® Ready antibody clones?
We do not test our antibodies by mass cytometry or on a CyTOF machine in-house. The data displayed on our website is provided by Fluidigm®. Please contact Fluidigm® directly for additional data and further details.
- Can I use Maxpar® Ready format clones for flow cytometry staining?
We have not tested the Maxpar® Ready antibodies formulated in solution containing EDTA for flow cytometry staining. While it is likely that this will work in majority of the situations, it is best to use the non-EDTA formulated version of the same clone for flow cytometry testing. The presence of EDTA in some situations might negatively affect staining.
- I am having difficulty observing a signal after conjugating a metal tag to your Maxpar® antibody. Please help troubleshoot.
We only supply the antibody and not test that in house. Please contact Fluidigm® directly for troubleshooting advice: http://techsupport.fluidigm.com/
- Is there a difference between buffer formulations related to Maxpar® Ready and purified format antibodies?
The Maxpar® Ready format antibody clones are formulated in Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. The regular purified format clones are formulated in solution that does not contain any EDTA. Both formulations are however without any extra carrier proteins.
|Purified anti-human CD61||VI-PL2||FC, CyTOF®, ICC, IHC-F, WB|
|FITC anti-human CD61||VI-PL2||FC|
|PE anti-human CD61||VI-PL2||FC|
|Alexa Fluor® 647 anti-human CD61||VI-PL2||FC, ICC|
|PerCP anti-human CD61||VI-PL2||FC|
|APC anti-human CD61||VI-PL2||FC|
|Purified anti-human CD61 (Maxpar® Ready)||VI-PL2||FC, CyTOF®|
|PE/Cyanine7 anti-human CD61||VI-PL2||FC|
|PerCP/Cyanine5.5 anti-human CD61||VI-PL2||FC|
|APC/Fire™ 750 anti-human CD61||VI-PL2||FC|
|Alexa Fluor® 700 anti-human CD61||VI-PL2||FC|
|TotalSeq™-A0372 anti-human CD61||VI-PL2||PG|
|PE/Dazzle™ 594 anti-human CD61||VI-PL2||FC|
|TotalSeq™-C0372 anti-human CD61||VI-PL2||PG|
|TotalSeq™-D0372 anti-human CD61||VI-PL2||PG|
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-human CD61
FITC anti-human CD61
PE anti-human CD61
Alexa Fluor® 647 anti-human CD61
PerCP anti-human CD61
APC anti-human CD61
Purified anti-human CD61 (Maxpar® Ready)
PE/Cyanine7 anti-human CD61
PerCP/Cyanine5.5 anti-human CD61
APC/Fire™ 750 anti-human CD61
Alexa Fluor® 700 anti-human CD61
TotalSeq™-A0372 anti-human CD61
PE/Dazzle™ 594 anti-human CD61
TotalSeq™-C0372 anti-human CD61
TotalSeq™-D0372 anti-human CD61