Purified anti-human CD45RA Recombinant Antibody

Pricing & Availability
Clone
QA19A34 (See other available formats)
Regulatory Status
RUO
Other Names
GP180, L-CA, LCA, LY5, T200, PTPRC
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA19A34_PURE_CD45RA_Antibody_051721
Human peripheral blood lymphocytes were stained with CD45RO FITC and CD45RA (clone QA19A34) purified (left) or mouse IgG1, κ purified isotype control (right) followed by anti-mouse IgG PE secondary antibody.
  • QA19A34_PURE_CD45RA_Antibody_051721
    Human peripheral blood lymphocytes were stained with CD45RO FITC and CD45RA (clone QA19A34) purified (left) or mouse IgG1, κ purified isotype control (right) followed by anti-mouse IgG PE secondary antibody.
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314802 100 µg £27.00
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Description

CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2892385 (BioLegend Cat. No. 314802)

Antigen Details

Structure
Tyrosine phosphatases, type I transmembrane (exon 4 splicing of CD45 gene), 205-220 kD
Ligand/Receptor
Galectin-1, CD2, CD3, CD4
Antigen References

1. Tian et al. 2017. Nat Commun. 8(1):1473
2. Kunert et al. 2019. J Immunother Cancer. 7(1):149

 

Gene ID
5788 View all products for this Gene ID
UniProt
View information about CD45RA on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05/17/2021

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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