- 11D8 (See other available formats)
- Regulatory Status
- Other Names
- Histone-H3, H3
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Histone H3 is phosphorylated at serine 10 during mitosis and is found to be involved in transcriptional activation, chromatin decondensation, and chromosome compaction during cell division, by the action of Aurora kinase and NIMA kinases.Product Details
- Antibody Type
- Host Species
- Modified synthetic peptide conjugated to KLH
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- The antibody was purified by antigen-affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
WB - Quality tested
IF - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 1 µg per ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
The histone H3 pS10 antibody recognizes phosphorylation of human H3 protein at Ser10 residue and has been shown to be useful for Western blotting.
- Product Citations
AB_10896911 (BioLegend Cat. No. 650801)
AB_10900065 (BioLegend Cat. No. 650802)
- H3 is part of the nucleosome, comprised of an octameric complex with H2A, H2B, and H4 proteins.
- H3 is a core component of the nucleosome that serves to wrap and compact DNA into chromatin. Histones, therefore, limit the accessibility of DNA, providing mechanisms for transcription regulation, DNA repair and replication, and chromosomal stability.
- Two molecules of H3 form a heterotetramer with two molecules of H4.
- Biology Area
- Cell Biology, Chromatin Remodeling/Epigenetics, DNA Repair/Replication, Transcription Factors
- Molecular Family
- Antigen References
1. Choi HS, et al. 2005. J. Biol. Chem. 280:13545.
2. Goto H, et al. 2002. Genes Cells 7:11.
3. Garcia BA, et al. 2005. Biochemistry 44:13202.
4. Hans F, et al. 2001. Oncogene 20:3021.
- H3 is regulated by acetylation, methylation, citrullination, phosphorylation, and ubiquitination.
- Gene ID
- 8290 View all products for this Gene ID
- View information about Histone H3 Phospho on UniProt.org
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