- 3B3C32 (See other available formats)
- Regulatory Status
- Other Names
- Apolipoprotein E, ApoE
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Full length mouse Apo-E recombinant protein expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2565426 (BioLegend Cat. No. 674802)
- 293 amino acids, predicted molecular weight of 34 kD (mature form), and contains one LDL receptor binding domain and two heparin binding regions.
- Apo-E is a component of serum chylomicron, VLDL, and HDL particles, and mediates lipid metabolism and memory formation.
- SET, KCNMA1, SAA, and PRNP.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Antigen References
1. Hayes EM, et al. 2014. Front Immunol. 5:537.
2. Kim J, et al. 2014. Mol. Cells 37:767.
3. Verghese PB, et al. 2013. Proc. Natl. Acad. Sci. USA 110:E1807.
4. Mahley RW, et al. 2012. Neuron 76:871.
5. Holtzman DM, et al. 2012. Cold Spring Harb. Perspect. Med. 2:a006312.
6. Zhang HL, et al. 2010. Clin. Dev. Immunol. 2010:186813.
- Gene ID
- 11816 View all products for this Gene ID
- View information about Apo E on UniProt.org
|Purified anti-Apo E||3B3C32||WB|
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