PE anti-human CD169 (Sialoadhesin, Siglec-1) Antibody

Pricing & Availability
7-239 (See other available formats)
Regulatory Status
Other Names
Sialic acid binding Ig-like lectin 1 (Siglec-1)
Mouse IgG1, κ
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Product Citations
IFN-γ + TNF-α stimulated human monocytes (day-3) stained with 7-239 PE
  • 7-239_PE_121509
    IFN-γ + TNF-α stimulated human monocytes (day-3) stained with 7-239 PE
See PE spectral data
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346003 25 tests £72.00
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346004 100 tests £185.00
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CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a 210 kD type I single membrane-spanning glycoprotein. It is the largest member of the Siglec family, consisting of 1709 amino acids and belonging to the immunoglobulin superfamily. CD169 is expressed by macrophages and dendritic cells. By its affinity to α2,3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B and T cells. Several CD169 counter receptors, such as CD227 on human breast cancer cells, CD43 on T cells and CD206 on macrophages, have been reported.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Human Rhinovirus (HRV14) infected, monocyte derived-DCs
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: Western blotting and inhibition of erythrocyte-rosetting with cells expressing CD169.

Application References

(PubMed link indicates BioLegend citation)
  1. Kirchberger S, et al. 2005. J. Immunol. 175:1145.
  2. Schrauf C, et al. 2009. J. Immunol. 183:4440.
Product Citations
  1. OhAinle M et al. 2018. eLife. 7 pii: e39823. PubMed
  2. Cassetta L et al. 2019. Cancer Cell. 35(4):588-602 . PubMed
  3. Okoye AA, et al. 2018. Nat Med. 24:1430. PubMed
  4. Perez–Zsolt D, et al. 2019. Front Immunol. 0.989583333. PubMed
  5. Leylek R, et al. 2019. Cell Rep. 29:3736. PubMed
  6. Heikema A, et al. 2013. Infect Immun . 81:2095. PubMed
  7. Kim WK, et al. 2015. AIDS Res Hum Retroviruses . 31: 696-706. PubMed
  8. Saito Y, et al. 2015. Cancer Immunol Res. 3: 1356 - 1363. PubMed
  9. Silvin A, et al. 2020. Cell. 182:1401. PubMed
  10. Ostendorf L, et al. 2021. Scientific Reports. 11(1):10299. PubMed
AB_2189030 (BioLegend Cat. No. 346003)
AB_2189029 (BioLegend Cat. No. 346004)

Antigen Details

Type I single membrane-spanning lectin, 1709 amino acids, 210 kD, belongs to the immunoglobulin superfamily

Macrophages, dendritic cells

Adhesion molecule
α-2,3-linked sialic acid
CD227, CD43 and CD206
Mediates sialic-acid dependent binding to granulocytes, monocytes, NK, B and T cells.
Cell Type
B cells, Dendritic cells, Macrophages
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules, Siglec Molecules
Antigen References

1. Xiong YS, et al. 2009. Clin. Biochem. 42:1057.
2. Varki A, et al. 2009. Glycoconj J. 26:231.
3. Rempel H, et al. 2008. PLoS One. 3:e1967.
4. Crocker PR, et al. 2001. Trends Immunol. 22:337.
5. Hartnell A, et al. 2001. Blood 97:288.

Gene ID
6614 View all products for this Gene ID
View information about CD169 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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