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PE anti-human ANTXR2 Antibody

Pricing & Availability
Clone
H8R23 (See other available formats)
Regulatory Status
RUO
Other Names
Capillary morphogenesis gene 2 (CMG2)
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
H8R23_PE_ANTXR2_Antibody_083120
Human peripheral monocytes were stained with anti-human CD16 Alexa Fluor® 700 and anti-human ANTXR2 (clone H8R23) PE (left) or mouse IgG1, κ PE isotype control (right). Dot plots are gated on monocyte population in human lysed whole blood.
  • H8R23_PE_ANTXR2_Antibody_083120
    Human peripheral monocytes were stained with anti-human CD16 Alexa Fluor® 700 and anti-human ANTXR2 (clone H8R23) PE (left) or mouse IgG1, κ PE isotype control (right). Dot plots are gated on monocyte population in human lysed whole blood.
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318403 25 tests £122
 
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318404 100 tests £271
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This product is scheduled for discontinuation. Please use the availability checker to determine current availability.
Description

ANTXR2 is a type I transmembrane protein, with an extracellular van Willebrand factor A (vWA) domain, an Ig-like domain, a single transmembrane helix and a cytoplasmic tail. It binds to the toxins of Bacillus anthracis, such as protective antigen (PA), in a divalent cation-dependent manner. Upon binding of the protective antigen (PA), the complex moves to glycosphingolipid-rich lipid rafts and internalized. In the endosomal membrane, the toxin-receptor complex forms a pore, which allows the other components of anthrax toxin to escape to the cytoplasm. It also binds to laminin, and possibly collagen type IV, which may indicate that this receptor involves in the formation of capillaries and maintenance the structure of basement membranes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
HCC827 GR2 cell line
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2876622 (BioLegend Cat. No. 318403)
AB_2876622 (BioLegend Cat. No. 318404)

Antigen Details

Structure
Type I transmembrane protein, with an extracellular van Willebrand factor A (vWA) domain, an Ig-like domain, a single transmembrane helix and a cytoplasmic tail. 54kD.
Distribution

ANTXR2 is expressed on T cell, B cell, dendritic cell, monocytes, and granulocytes.

Function
The ANTXR2 protein acts as a receptor for the toxin that causes anthrax, allowing the toxin to attach to cells and trigger disease. The ANTXR2 protein is also involved in the formation of capillaries and maintaining the structure of basement membranes.
Ligand/Receptor
Protective antigen (PA), laminin, collagen type IV
Cell Type
B cells, Dendritic cells, Granulocytes, Monocytes, T cells
Biology Area
Bacterial proteins and Toxins
Molecular Family
Adhesion Molecules
Antigen References
  1. Burgi J, et al. 2017. Nature Comms. 8:15861
  2. Scobie H, et al. 2003. Proc. Natl. Acad. Sci. USA. 100:5170
Gene ID
118429 View all products for this Gene ID
UniProt
View information about ANTXR2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 08/31/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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