- S-HCL-3 (See other available formats)
- Regulatory Status
- Other Names
- Integrin αX subunit, CR4, p150, ITGAX
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.Product Details
- Antibody Type
- Host Species
- Spleen cells from patient diagnosed with hairy cell leukemia.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 510™ under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Brilliant Violet 510™ excites at 405 nm and emits at 510 nm. The bandpass filter 510/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 510™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Becton, Dickinson and Company and its affiliates. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. patent(s), pending patent applications and/or foreign equivalents.
- Excitation Laser
Violet Laser (405 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemistry on frozen tissue sections1,2,3,4 and immunoprecipitation1.
(PubMed link indicates BioLegend citation)
- Schwarting R, et al. 1985. Blood 65:974.
- Knowles DM, et al. 1990. Am. J. Pathol. 136:29.
- Vandenabeele S, et al. 2001. Blood 97:1733.
- Shaw JL, et al. 2011. J. Reprod. Immunol. 89:84.
- Product Citations
AB_2650796 (BioLegend Cat. No. 371513)
AB_2650797 (BioLegend Cat. No. 371514)
- Integrin, type I transmembrane glycoprotein, associates with integrin ß2 (CD18), 145-150 kD.
Myeloid, dendritic cells, NK cells, B cells and T cell subsets.
- Adhesion and CTL killing.
- Interacts with fibrinogen, CD54, and iC3b.
- CD54, fibrinogen, iC3b, ICAM-1, ICAM-4
- Cell Type
- B cells, Dendritic cells, NK cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
1. Petty HR, Todd RF 3rd. 1996. Immunol. Today 17:209.
2. Springer T. 1994. Cell 76:301.
3. Ihanus E, et al. 2007. Blood 109:802-10.
- Gene ID
- 3687 View all products for this Gene ID
- View information about CD11c on UniProt.org
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