- TDP2H4 (See other available formats)
- Regulatory Status
- Other Names
- TAR DNA-binding protein-43, TDP 43, TARDBP, ALS10
- Rat IgG2a
- Ave. Rating
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- Product Citations
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TDP43, also known as TARDBP, was originally identified as a protein that binds to the transactivation response (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome. TDP43 contains two copies of a ~90 amino acid RNA recognition motif (RRM) found in many proteins, which bind single stranded RNA. Recent research has shown that hyperphosphorylated, ubiquitinated, and N-terminally truncated TDP43 is the pathological hallmark lesion in most familial and sporadic forms of FTLD-U and ALS (1).Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 2.0 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is effective in immunoblotting (WB) and immunohistochemistry (IHC).
Expected Staining Pattern: Nuclear
(PubMed link indicates BioLegend citation)
- Neumann M. 2009. Int. J. Mol. Sci. 10.3390/ijms10010232.
AB_2750118 (BioLegend Cat. No. 808303)
AB_2750119 (BioLegend Cat. No. 808304)
- TDP43 is a 414 amino acid protein with an apparent molecular mass of 45 kD.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Gene ID
- 23435 View all products for this Gene ID 230908 View all products for this Gene ID 100174676 View all products for this Gene ID
- View information about TDP43 on UniProt.org
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
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