- 10E5 (See other available formats)
- Regulatory Status
- Other Names
- DNAM-1, PTA1 (platelet and T cell activation antigen 1), TLISA1, LFA-1 associated Molecule PTA-1
- Rat IgG2b, κ
- Ave. Rating
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- Product Citations
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CD226 (DNAM-1) is constitutively expressed on native CD8+ cells and on CD4+ T cells, macrophages and NK cells.This antibody (10E5) was reported to bind about 40% of inactivated CD4+ cells and binds only to differentiated Th1 cells, but not to Th2 or Th0 cells.It is also reported to suppress antigen-specific T cell expansion and EAE (experimental allergic encephalitis) mediated by Th1 cells.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Th1 polarized T cell clones
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 787 nm.
(PubMed link indicates BioLegend citation)
- Dardalhon V, et al. 2005. J. Immunol. 175:1558
- Huang Z, et al. 2011. J Immunol. 186:3421. PubMed
AB_2632820 (BioLegend Cat. No. 128815)
AB_2632821 (BioLegend Cat. No. 128816)
- 65 kd glycoprotein of a member of Ig-superfamily containing 2 immunologlobulin-like domains.
Expressed on majority of CD4+ and CD8+ T cells, NK cells, monocytes/macrophages and a subset of B cells and thymocytes. Reported to be specifically expressed on the surface of Th1 cells, but downregulated in Th2 cells.
- Mediates cellular adhesion, involved in LFA-1 costimulatory signal for T cell differentiation and proliferation
- CD112 and CD155
- Cell Type
- B cells, Macrophages, Monocytes, NK cells, T cells, Th1
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1.Tahara Hanaoka S, et al. 2006. Blood 107:1491
2. Shibuya K, et al. 2003. J. Exp. Med. 198:1829
- Gene ID
- 225825 View all products for this Gene ID
- View information about CD226 on UniProt.org
|FITC anti-mouse CD226 (DNAM-1)||10E5||FC|
|PE anti-mouse CD226 (DNAM-1)||10E5||FC|
|Alexa Fluor® 647 anti-mouse CD226 (DNAM-1)||10E5||FC|
|APC anti-mouse CD226 (DNAM-1)||10E5||FC|
|PE/Cyanine7 anti-mouse CD226 (DNAM-1)||10E5||FC|
|PerCP/Cyanine5.5 anti-mouse CD226 (DNAM-1)||10E5||FC|
|APC/Fire™ 750 anti-mouse CD226 (DNAM-1)||10E5||FC|
|PE/Dazzle™ 594 anti-mouse CD226 (DNAM-1)||10E5||FC|
|Biotin anti-mouse CD226 (DNAM-1)||10E5||FC|
|Purified anti-mouse CD226 (DNAM-1)||10E5||FC, IHC-F, IP|
|TotalSeq™-A0852 anti-mouse CD226 (DNAM-1)||10E5||PG|
|TotalSeq™-C0852 anti-mouse CD226 (DNAM-1) Antibody||10E5||PG|
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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FITC anti-mouse CD226 (DNAM-1)
PE anti-mouse CD226 (DNAM-1)
Alexa Fluor® 647 anti-mouse CD226 (DNAM-1)
APC anti-mouse CD226 (DNAM-1)
PE/Cyanine7 anti-mouse CD226 (DNAM-1)
PerCP/Cyanine5.5 anti-mouse CD226 (DNAM-1)
APC/Fire™ 750 anti-mouse CD226 (DNAM-1)
PE/Dazzle™ 594 anti-mouse CD226 (DNAM-1)
Biotin anti-mouse CD226 (DNAM-1)
Purified anti-mouse CD226 (DNAM-1)
TotalSeq™-A0852 anti-mouse CD226 (DNAM-1)
TotalSeq™-C0852 anti-mouse CD226 (DNAM-1) Antibody