Ultra-LEAF™ Purified anti-mouse/human CD351 (Fc α/µ receptor) Antibody

Pricing & Availability
TX61 (See other available formats)
Regulatory Status
HCDM listed
Other Names
Fcα/µ receptor, Fcα/µR
Mouse IgG1, κ
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Product Citations
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137307 100 µg 216€
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137308 1 mg 595€
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Fcα/µ receptor (Fcα/µR), CD351, is a type I transmembrane protein with an Ig-like domain in extracellular portion.  It is a novel Fc receptor for IgM and IgA.  Fcα/µ receptor mRNA has been found in thymus, spleen, liver, kidney, intestines, testes, placenta, and T cell leukemia cell lines.  Fcα/µ receptor protein expression is detected on B cells, macrophages, and activated T cells.  Fcα/µ receptor mediates primary B lymphocyte endocytosis of IgM-coated Staphylococcus aureus.   It is involved in the primary stages of the immune response to microbes.

Product Details
Technical data sheet

Product Details

Mouse, Human
Antibody Type
Host Species
mFcα/µ receptor transfected Ba/F3 cells
0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Endotoxin level is < 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.

FC - Quality tested
Block - Reported in the literature

Recommended Usage

Each lot of this antiboday is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported (for relevant formats) application include: blocking binding of both IgM and IgA to the mFcα/µ receptor2.

Application References

(PubMed link indicates BioLegend citation)
  1. Cho Y, et al. 2006. Biochem. Biophys. Res. Commun. 345:474.
  2. Shibuya A, et al. 2006. Springer Semin. Immunopathol. 28:377.
  3. Anguetil F, et al. 2015. J Immunol. 194:3664. PubMed
AB_2888886 (BioLegend Cat. No. 137307)
AB_2888886 (BioLegend Cat. No. 137308)

Antigen Details

About 70 kD transmembrane glycoprotein with an Ig-like domain in extracellular portion.

B cells, macrophages, and activated T cells.

Mediate primary B lymphocyte endocytosis and involve in the primary stages of the immune response to microbes.
IgA and IgM
Cell Type
B cells, Macrophages, T cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Shibuya A, et al. 2000. Nat. Immunol. 1(5):441.
2. Sandor M, et al. 1992. J. Immunol.. 148(8):2363.
3. Cho Y, et al. 2010. Mol. Immunol. 47(4):878.

Gene ID
14125 View all products for this Gene ID 83953 View all products for this Gene ID
View information about CD351 on UniProt.org

Related FAQs

Do you guarantee that your antibodies are totally pathogen free?

BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.

Does BioLegend test each Ultra-LEAF™ antibody by functional assay?

No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.

Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?

No, BioLegend does not test for pathogens in-house unless otherwise indicated.  However, we can recommend an outside vendor to perform this testing as needed.

Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?

We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.

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For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • PE anti-mouse/human CD351 (Fc α/µ receptor)

  • Ultra-LEAF™ Purified anti-mouse/human CD351 (Fc α/µ receptor)


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