Purified anti-human CXCL10 (IP-10) Antibody

Pricing & Availability
J036G3 (See other available formats)
Regulatory Status
Other Names
Interferon gamma-inducible protein 10 (IP10), Interferon gamma induced factor, gIP-10, IFI10, INP10
Mouse IgG2a, κ
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Product Citations
  • J036G3_PURE_CXCL10_Antibody_1_ELISA_051316
  • J036G3_PURE_CXCL10_Antibody_2_WB_051316
    Western blot analysis of 50 ng of recombinant human CXCL10 (IP-10) (lane 1) and 50 ng of recombinant mouse CXCL10 (IP-10) (lane 2) using anti-human CXCL10 (IP-10) (clone J036G3) antibody.
Cat # Size Price Quantity Check Availability Save
524401 50 µg 76€
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524402 500 µg 260€
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CXCL10 is an ELR-negative chemokine structurally and functionally related to CXCL9 and CXCL11.  CXCL10, CXCL9, and CXCL11 are produced and secreted by monocytes, macrophages, fibroblasts, and epithelial cells upon stimulation with proinflammatory cytokines, especially IFNγ. CXCL10 chemoattracts CD4, CD8, and NK and NKT cells through the binding to its receptor CXCR3, which is shared with CXCL9 and CXCL11. In addition, CXCL10 inhibits neovascularization in tumors and in wound healing in vivo. Also, CXCL10 has anti-proliferative effects on endothelial cells in vitro, and angiostatic and antitumor effects in vivo. It has been suggested that the anti-proliferative effect of CXCL10 in endothelial cells is CXCR3-independent and that it is mediated through GAG interaction. CXCL10 also possesses antimicrobial activity against E. coli and L. monocytogenes, and both the spore and bacillus forms of B. anthracis. CXCL10 expression is strongly upregulated in many human inflammatory diseases, including rheumatoid arthritis, type I diabetes, multiple sclerosis, atherosclerosis, allograft rejection, and others.     

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Recombinant human CXCL10
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

ELISA Capture - Quality tested
WB - Verified

Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 1-4 µg/ml is recommended. To obtain a linear standard curve, serial dilutions of CXCL10 (IP-10) recombinant protein ranging from 2000 to 31.3 pg/ml are recommended for each ELISA plate. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

ELISA Capture: The purified J036G3 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated Poly5194 antibody (Cat. No. 519403) as the detecting antibody and recombinant human CXCL10 (IP-10) (Cat. No. 573509) as the standard.

Note: For testing human CXCL10 (IP-10) in serum, plasma or supernatant, BioLegend's ELISA LEGEND MAX™ Kits (Cat. No. 439907 & 439908) are specially developed and recommended.

Product Citations
  1. Gruber CN, et al. 2020. Cell. 183:982. PubMed
AB_2562398 (BioLegend Cat. No. 524401)
AB_2562399 (BioLegend Cat. No. 524402)

Antigen Details

Interferon gamma-stimulated keratinocytes, monocytes, macrophages, fibroblasts, endothelial, T cells
CXCL10 chemoattracts CD4, Th1, CD8, NK, and NKT cells. CXCL10 is induced by inflammatory cytokines, and NH2-terminal cleavage of CXCL10 by DPP-IV/CD26 impairs its chemoattracting capacity and CXCR3 signaling.
Activated T cells, Th1 cells, regulatory T cells, NK cells, NKT cells, endothelial cells, fibroblasts, endothelial cells
Cell Type
Monocytes, Macrophages, Fibroblasts, Endothelial cells, T cells
Biology Area
Cell Biology, Neuroinflammation, Neuroscience
Molecular Family
Antigen References

1. Luster AD, et al. 1985. Nature 315:672.
2. Loos T, et al. 2008. Blood 112:2648.
3. Crawford MA, et al. 2009. Infect. Immun. 77:1664.
4. Campanella GS, et al. 2010. PLoS One 5:e12700.
5. Hoerning A. 2011. Eur. J. Immunol. 41:2291.

Gene ID
3627 View all products for this Gene ID
View information about CXCL10 on UniProt.org

Related FAQs

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Go To Top Version: 3    Revision Date: 06.01.2016

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  • Purified anti-human CXCL10 (IP-10)


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