- NSE-P2 (See other available formats)
- Regulatory Status
- Other Names
- Gamma-enolase, neural enolase, neuron-specific enolase, 2-phospho-D-glycerate hydrolyase, ENO2, NSE
Covance Catalog# MMS-519P
- Mouse IgG1, κ
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- Product Citations
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Neuron specific enolase is found in elevated concentrations in plasma and certain neoplasias. These include pediatric neuroblastoma and small cell lung cancer.
Neuron specific enolase (NSE) converts 2-phosphoglycerate to phosphoenolpyruvate in the glycolytic pathway, and the reverse reaction in gluconeogenesis. It is one of three mammalian enolases, which are also known as ENO1, ENO2, and ENO3 or as enolase alpha, beta and gamma. The three enolases have different cell type specific expression patterns, so that antibodies to them are useful cell type specific markers. NSE corresponds to ENO2 or enolase gamma and is heavily expressed in neuronal cells. Neurons require a great deal of energy and have high levels of glycolytic enzymes such as NSE. Antibodies to this NSE are useful for identifications of neuronal cell bodies, developing neuronal lineage and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood has also been used as a biomarker of neuronal injury.
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This antibody was raised against a synthetic peptide corresponding to amino acids 271-285. It recognizes the sequence TGDQLGALYQDFVRD.
- Phosphate-buffered solution + 0.03% thimerosal.
- The antibody was purified by affinity chromatography.
- 1 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
IHC-P - Quality tested
WB, ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 µg/mL is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg per mL. For immunocytochemistry, a concentration range of 0.5 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2564666 (BioLegend Cat. No. 804501)
- Expected MW: 47 kD
- Cell Type
- Mature Neurons, Neural Stem Cells
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- Antigen References
- Murray GI, et al. 1993. J Clin Pathol. 46:993.
- Duncan ME, et al. 1992. J immunol Methods. 151:227
- Gene ID
- 2026 View all products for this Gene ID
- View information about NSE on UniProt.org
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