- A18010A (See other available formats)
- Regulatory Status
- Other Names
- Eukaryotic Translation Initiation Factor 4E Binding Protein 1, Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1, PHAS-I
- Mouse IgG1, κ
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- Product Citations
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In eukaryotes, the mTOR kinase signaling pathway links cell growth and proliferation with nutrient availability. Under nutrient-deplete conditions, eukaryotic translation initiations factor 4E-binding protein 1 (4EBP1) binds the general translation factor eIF4E, resulting in an attenuation of cap-dependent translation. Under nutrient-replete conditions, mTORC1 and mTORC2 complexes phosphorylate 4EBP1 at Threonine 70 and disrupt the formation of the 4EBP1-eIF4E complex, thereby alleviating the repressive function of 4EBP1.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Synthetic peptide corresponding to human 4EBP1 phosphorylated at Threonine 70
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This clone has not been tested for ICC and IP.
AB_2814468 (BioLegend Cat. No. 619601)
AB_2814469 (BioLegend Cat. No. 619602)
- 4EBP1 is a 118 amino acid protein with a predicted molecular weight of 13 kD.
Cytosol and nucleus/ubiquitously expressed
- Regulation of global translation
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Protein Synthesis, Signal Transduction
- Molecular Family
- Antigen References
- Brunn GJ, et al. 1997. Nature. 277:99.
- Hara K, et al. 2002. Cell. 110:177.
- Ekim B, et al. 2011. Mol. Cell Biol. 31:2787.
- Gene ID
- 1978 View all products for this Gene ID
- View information about 4EBP1 on UniProt.org
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