- B6.220 (See other available formats)
- Regulatory Status
- Other Names
- Insulin Receptor
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD220, also known as insulin receptor, is a type I transmembrane receptor tyrosine kinase composed of two extracellular α-subunits and two transmembrane β-subunits. Binding insulin, the insulin receptor forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. Activation of insulin receptor leads to subsequent downstream signaling in metabolic regulation, inducing glucose uptake, cell growth, differentiation, and apoptosis. Gene mutation in the insulin receptor or decreased insulin receptor signaling leads to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus (diabetes mellitus type 2). Most normal cells constitutively express insulin receptors. In hematopoietic cells, insulin receptor is constitutively expressed on monocytes and selectively expressed on activated lymphocytes.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Human insulin receptor/freund's adjuvant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Kim HK, et al. 2012. PloS One. 7:e45454. PubMed.
- Product Citations
AB_10898328 (BioLegend Cat. No. 352603)
AB_10933245 (BioLegend Cat. No. 352604)
- Consist of two alpha subunits and two beta subunits; the beta subunit passes through the cellular membrane and is linked by disulfide bonds.
- Hematopoietic and non hematopoietic cells.
- Regulates cell metabolism and growth.
- Ectonucleotide pyrophosphatase/phosphodiesterase, PTPN11, GRB10, GRB7, PRKCD, IRS1, SH2B1 and Mothers against decapentaplegic homolog 2.
- Biology Area
- Cell Biology, Immunology, Protein Synthesis, Signal Transduction
- Molecular Family
- CD Molecules, Protein Kinases/Phosphatase
- Antigen References
1. Viardot A, et al. 2006. Endocrinology 148:346.
2. Ward CW, et al. 2009. Bioessays 31:422.
3. Brindle NP, et al. 1990. Biochem. J. 268:615.
- Gene ID
- 3643 View all products for this Gene ID
- View information about CD220 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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