Loading...

APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
Cat # Size Price Quantity Check Availability Save
123115 25 µg 40€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
123116 100 µg 115€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  2. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  3. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  4. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  5. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  6. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  7. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  8. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  9. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  10. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  11. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  12. Yang D, et al. 2022. Cell. 185:1905. PubMed
  13. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  14. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  15. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  16. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  17. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  18. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  19. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  20. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  21. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  22. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  23. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  24. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  25. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  26. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  27. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  28. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  29. Kim SE, et al. 2019. Nutrients. 11. PubMed
  30. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  31. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  32. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  33. He R, et al. 2021. J Immunol. 206:2353. PubMed
  34. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  35. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  36. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  37. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  38. He F, et al. 2021. J Exp Med. 218:. PubMed
  39. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  40. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  41. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  42. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  43. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  44. Dong L, et al. 2021. Cancer Cell. . PubMed
  45. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  46. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  47. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  48. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  49. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  50. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  51. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  52. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  53. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  54. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  55. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  56. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  57. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  58. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  59. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  60. Sun P, et al. 2015. J Hepatol. . PubMed
  61. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  62. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  63. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  64. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  65. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  66. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  67. Han J, et al. 2022. FEBS J. 289:417. PubMed
  68. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  69. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  70. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  71. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  72. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  73. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  74. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  75. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  76. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  77. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  78. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  79. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  80. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  81. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  82. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  83. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  84. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  85. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  86. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  87. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  88. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  89. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  90. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  91. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  92. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  93. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  94. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  95. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  96. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  97. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  98. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  99. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  100. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  101. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  102. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  103. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  104. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  105. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  106. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  107. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  108. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  109. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  110. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  111. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  112. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  113. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  114. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  115. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  116. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  117. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  118. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  119. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  120. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  121. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  122. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  123. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  124. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  125. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  126. Oatley J, et al. 2009. Development. 136:1191. PubMed
  127. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  128. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  129. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  130. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  131. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  132. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  133. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  134. Lv F, et al. 2022. iScience. 25:103639. PubMed
  135. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  136. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  137. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  138. Gao H, et al. 2021. Cells. 10:. PubMed
  139. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  140. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  141. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  142. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  143. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  144. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  145. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  146. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  147. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  148. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  149. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  150. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  151. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  152. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  153. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  154. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  155. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  156. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  157. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  158. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  159. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  160. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  161. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  162. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  163. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  164. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  165. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  166. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  167. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  168. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  169. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  170. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  171. Matundan H, et al. 2019. J Virol. 93. PubMed
  172. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  173. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  174. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  175. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  176. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  177. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  178. Yang Y, et al. 2022. Elife. 11:. PubMed
  179. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  180. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  181. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  182. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  183. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  184. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  185. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  186. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  187. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  188. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  189. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  190. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  191. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  192. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  193. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  194. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  195. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  196. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  197. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  198. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  199. Lang V, et al. 2021. Elife. 10:. PubMed
  200. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  201. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  202. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  203. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  204. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  205. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  206. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  207. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  208. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  209. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  210. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  211. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  212. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  213. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  214. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  215. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  216. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  217. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  218. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  219. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  220. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  221. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  222. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  223. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  224. Deng W, et al. 2015. Clin Immunol. . PubMed
  225. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  226. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  227. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  228. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  229. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  230. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  231. Engblom C, et al. 2017. Science. 358:6367. PubMed
  232. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  233. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  234. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  235. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  236. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  237. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  238. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  239. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  240. Calle P, et al. 2021. Cells. 10:. PubMed
  241. Horsle B 2013. Development. 140:1517. PubMed
  242. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  243. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  244. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  245. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  246. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  247. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  248. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  249. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  250. Karki R, et al. 2020. bioRxiv. . PubMed
  251. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  252. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  253. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  254. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  255. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  256. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  257. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  258. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  259. Karki R, et al. 2021. Cell. 184:149. PubMed
  260. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  261. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  262. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  263. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  264. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  265. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  266. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  267. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  268. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  269. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  270. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  271. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  272. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  273. Gu H, et al. 2021. Elife. 10:. PubMed
  274. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  275. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  276. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  277. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  278. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  279. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  280. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  281. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  282. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  283. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  284. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  285. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  286. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  287. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  288. Liu SS, et al. 2021. Immunity. :. PubMed
  289. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  290. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  291. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  292. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  293. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  294. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  295. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  296. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  297. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  298. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  299. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  300. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  301. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  302. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  303. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  304. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  305. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  306. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  307. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  308. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  309. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  310. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  311. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  312. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  313. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  314. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  315. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  316. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  317. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  318. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  319. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  320. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  321. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  322. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  323. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  324. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  325. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  326. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  327. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  328. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  329. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  330. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  331. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  332. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  333. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  334. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  335. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  336. Lalor R, et al. 2019. Nutrients. 11. PubMed
  337. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  338. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  339. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  340. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  341. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 10.25.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere
Login / Register
Remember me
Forgot your password? Reset password?
Create an Account